Karachi South District (Sindhi: ضلعو ڏکڻ ڪراچی ‎ Urdu: ضلع کراچی جنوبی ‎) is an administrative district of Karachi Division in Sindh, Pakistan. It is located in the southern part of Karachi.

Karachi South District is the economic backbone of the country. It has Head Offices of many Corporations, Companies and Banks. Governor House, Chief Minister House, Sindh Assembly, High Court, Embassies and Consulates of different countries and other government offices are also located there.

The district was abolished in 2000, and was divided into three towns namely: Jamshed Town, Lyari Town and Saddar Town.

On 11 July 2011, the Sindh Government restored again Karachi South District.

In November 2013, Jamshed Town was added into Karachi East District, after three eastern towns of that district split up to form a new district named Korangi. Now Karachi South comprises two towns: Lyari and Saddar.